In the year 2006, Thamanna made her debut as heroine in the Tamil film Kedi. After this she continued to act in many Tamil films including Dhanush starrer Padikadhavan, Surya starrer Ayan and Karthi starrer Paiyaa and Siruthai.
After this she did not get any Tamil offers. Because of this, she switched over to Telugu films. She is now acting in numerous Telugu films. After a long gap she has now got an opportunity to pair with Ajith in a film to be directed by Shiva who had earlier directed Siruthai.
When asked her that why she is not getting Tamil offers in spite of her being a leading actress, she angrily said, “The films Ayan, Padikadhavan and Siruthai in which I have acted were great hits. In spite of this, I did not get Tamil films. I did not get offers because some people prevented me from getting offers. I will openly mention the names of those people at the appropriate time.”